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This is your health side to the topic of “Urology at the Costa Blanca” .

 

To call a urologist a mens doctor - compared to the gynaecologist as a womens doctor - is insufficient. The urologist is the specialist for kidneys, bladder, prostate, penis and testicles also cares for the virility and incontinence. Women, too can have problems of the kidneys, bladder and incontinence.

 

Due to the age pattern of my urology patients about 60% of my patients have cancer. For every cancer is different it is important to have a “complete therapy approach”. To treat only the disease without recognizing personal and cultural aspects or the family atmosphere will be of no pleasing result for the patient or the doctor.

 

It would be imprudent to believe that a doctor can everything and knows everything. That is why teamwork with colleagues locally and telephone conversations with the doctors in the “home-countries” of my patients will bring an optimum of therapeutical success.

 

 

I invite you to be introduced to the world of urology through my website…

 

 

Your Dr. Thomas Keul

 

 

 

 

 

 

5-Alpha-Rdecutase-Inhibitor reduces prostatecancer risk Print E-mail
Donnerstag, 30 April 2009
Dutasteride (Avodart), a commonly prescribed drug to treat benign prostatic hyperplasia, has been shown to lower the risk of prostate cancer by 23 percent in men with an increased risk of the disease, according to results of an international clinical trial presented today at the American Urological Association (AUA) Annual Meeting in Chicago. Data from the REDUCE Trial is being presented to members during the plenary session, and lead investigator Gerald Andriole, MD, of Washington University School of Medicine in St. Louis, will hold a special session for interested media at 12:15 p.m. in the AUA Press Suite.
The REDUCE trial is the first to examine chemoprevention for prostate cancer in men at increased risk for the disease. The trial involved 8,200 men ages 50 – 75 who were randomly assigned to receive a placebo or a daily 0.5 mg dose of dutasteride. Men in the study had elevated PSA levels (2.5 – 10 ng/ml) indicating that they were at increased risk of prostate cancer.
They had undergone biopsies that found no evidence of cancer within six months prior to enrolling in the trial. Therefore these men either did not have prostate cancer or possibly had microscopic tumors that were too small to be detected by the pre-study biopsy. The investigators performed scheduled biopsies on the men two years after they enrolled in the study and again after four years. After two years, prostate cancer was found in 17.2 percent of the men who took a placebo, compared with 13.4 percent who took dutasteride. After four years, prostate cancer was diagnosed in another 11.8 percent of men who received a placebo and 9.1 percent who received dutasteride. "In these men, the most likely explanation is that dutasteride worked by shrinking tumors and/or slowing their growth, thereby making them less likely to be detected by a biopsy," Dr. Andriole said. “This drug has the potential to offer many thousands of men a way to reduce their risk of being diagnosed with prostate cancer and, as a result, more men could avoid treatment for prostate cancer and the cost and unwanted side effects associated with treatment.”
The investigators found that there was no greater risk for the men who did develop prostate cancer to have aggressive tumors. This outcome was closely watched because an earlier trial of a similar BPH drug – finasteride (Proscar) – produced controversial results with regard to the risk of more aggressive tumors in those men who developed prostate cancer while on finasteride. An initial analysis of the finasteride data suggested that there was an increased risk for men to have prostate cancer with higher Gleason scores but a later analysis suggested that there is probably no greater risk for these men to develop higher grade prostate cancer. Over the course of the current study, 6.8 percent of men in the placebo group and 6.7 percent of men in the dutasteride group were found to have aggressive, high-grade tumors, defined as a Gleason score of 7 – 10. “We are very encouraged by this finding,” Dr. Andriole says. “Clearly, the data show dutasteride did not lead to more high-grade tumors, even though they would have been easier to detect in the dutasteride-treated men due to their smaller prostates.”
The REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trial was conducted at 250 sites in 42 countries around the world. The study was funded by GlaxoSmithKline. Dr. Andriole is chairman of the REDUCE steering committee and a consultant for the company.
 
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